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Two ice-themed commissions in a row! The title should explain the concept... I hope you don't mind that I didn't draw her whole body, I thought this emphasized her face better and gave me more room for details!
I've seen a lot of stuff that this reminds me of. Rei Ayaname being tentacled by an Angel in Neon Genesis Evangeleon. Movie Rogue from X-Men touching Wolverine a little too long in the first movie. Someone f***ing Paris Hilton on that one Robot Chicken sketch.
Her expression really makes her look all the more like this. She's definitely dying of some horribly painful disease. I've also seen insane blood pressure levels make veins visible, but not discolored as these obviously are.